Erectile Dysfunction
March 5, 2024

The Ultimate Guide to Understanding the Side Effects of Tadalafil

Tadalafil is a widely used prescription medication for treating erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). While it is effective in improving sexual function, it's essential for users to be aware of its potential side effects.

No items found.

Recap: what is Tadalafil?

Tadalafil, the generic version of Cialis, is a phosphodiesterase type 5 (PDE5) inhibitor. It's the same active ingredient found in Cialis, used in various medications to treat erectile dysfunction (ED) and, in some cases, benign prostatic hyperplasia (BPH).

Other ED medications require planning and timing your pill intake close to sexual activity. Tadalafil on the other hand, offers a longer duration of action, allowing for greater spontaneity when the mood strikes. 

Common Side Effects of Tadalafil

Tadalafil may cause a range of side effects, from mild to severe and short-term to long-term. These can vary depending on the dosage and other factors such as individual response. 

Short-term Side Effects

  • Headaches (most common side effect)
  • Muscle Aches within the first 12-24 hours of use)
  • Nasal Congestion 
  • Flushing
  • Indigestion

Side Effects by Dosage

Tadalafil 2.5 mg and 5 mg (Daily Use):

2 tables of Tadalafil 5mg

Lower doses of Tadalafil, designed for daily use, are gentler on your body. With a lower dosage, the chances of experiencing side effects are generally reduced. 

This approach focuses on gradually managing ED while minimising any discomfort.

Tadalafil 10 mg and 20 mg (Taken As Needed):

2 tablets of Tadalafil 20mg

When taking larger doses as necessary, there is a higher likelihood of encountering stronger side effects. 

This is due to the body processing a higher concentration of the medication, leading to a more intense response. It's a trade-off for quicker and more powerful help with ED.

Specific Side Effects and Concerns

Blood Pressure Variations 

Tadalafil relaxes blood vessel muscles, causing blood pressure to drop as vessels widen and blood flow increases. This can lead to an overall decrease in blood pressure.

Heart-Related Side Effects

Tadalafil may be risky for those with heart issues, as it can strain the heart by lowering blood pressure through vessel dilation. This strain is especially concerning for individuals with weak or damaged hearts.

Liver and Kidney Effects

Tadalafil can affect liver and kidney function, especially in those with existing issues. It may worsen current problems or alter how other medications are metabolised in the body.

Muscle Aches and Leg Pain 

After using Tadalafil, muscle aches and leg pain may occur, especially after increased physical activity. These discomforts are often a result of the body adjusting to the heightened blood flow.

Other Effects

Headaches and dizziness are common side effects of Tadalafil, making it hard to focus on daily tasks or enjoy your day. Your body typically reacts this way to the medication at first.

Side Effects in Special Conditions

Mixing with Alcohol

A pint of beer

Combining Tadalafil with alcohol may raise the chances of having side effects, especially those concerning your blood pressure. Alcohol can already decrease your blood pressure, so when mixed with Tadalafil, it could lower it further. This might result in symptoms such as dizziness, headaches, or feeling lightheaded, especially when standing up fast.

Mixing with Other Medications

You can combine Tadalafil with other medications, but it's important to consult your doctor first to ensure safety. Here's what you need to know:

1. Premature Ejaculation (PE) Medications (like Dapoxetine): It's generally safe to use these medications along with Tadalafil for PE issues, but always get approval from your doctor.

2. Blood Pressure Medications: Some blood pressure medicines can be taken with Tadalafil. Your doctor will monitor your blood pressure closely to prevent it from dropping too low.

3. Prostate Meds or Alpha-Blockers: These medications are commonly used for prostate problems or high blood pressure. Your doctor will make necessary adjustments to avoid low blood pressure.

4. Antifungals, HIV Meds, and Some Antibiotics: These medications often require dosage adjustments when taken with Tadalafil. It's crucial to discuss this with your doctor.

However, it's not recommended to mix Tadalafil with other ED medications like Sildenafil. This can pose serious health risks, such as very low blood pressure. Stick to one ED medication at a time and follow your doctor's advice for a safe approach.

Effects on Specific Groups

The Elderly

Older folks may experience stronger side effects from Tadalafil due to changes in how their bodies process medications as they age. This can result in the medication staying in the system longer, potentially causing more intense side effects such as headaches and muscle aches.

Men with Pre-existing Conditions:

Individuals with pre-existing health conditions, such as severe diabetes, high blood pressure, or specific genetic eye diseases, may find that Tadalafil complicates their health situation further by increasing the intensity or risk of side effects.

Long-term Use

Using Tadalafil for a long time brings up a few things you and your doctor need to keep an eye on:

Chronic Use Concerns

If you're taking Tadalafil regularly over years, it's smart to check how it's affecting your heart and blood vessels since it affects your blood flow. You'll want to catch any signs early if it's starting to cause problems.

The same can be said for heart health. Since Tadalafil impacts how blood moves through your body, it's important to notice any changes in your heart or blood pressure that might need attention.

Potential for Dependence

Becoming dependent on Tadalafil is not really about your body requiring it, but rather about feeling like you cannot engage in sexual activity without it.

It is more of a psychological matter, where you may feel less confident without the medication. Discussing this with your doctor can help you find a suitable balance.

Changes in Efficacy

After using Tadalafil for some time, you may notice that it is not as effective as it used to be.

This could be due to your body becoming accustomed to it, or perhaps other health problems are influencing its effectiveness.

Managing and Mitigating Side Effects

Dealing with the side effects of Tadalafil doesn't have to be troublesome. Here's how you can keep things under control:

Strategies to Reduce Side Effects

By making a few adjustments in your daily routine, you can reduce the occurrence of side effects. This may involve changing your diet, adjusting the timing of your medication, or making other lifestyle changes. 

Even small modifications can have a significant impact on your overall well-being.

When Side Effects Go Away

If you are experiencing mild and bothersome side effects, they often improve naturally as your body becomes accustomed to the medication.

Just be patient and with time, you may notice those troublesome issues gradually disappearing.

Uncommon and Rare Side Effects

Liver Function

Your liver helps clean drugs out of your system, and since it processes Tadalafil, long-term use could make it work harder. 

Keeping an eye on these can help your doctor adjust your treatment if needed, ensuring your liver stays in good shape.

Vision and Hearing Anomalies

Rarely, individuals using Tadalafil may experience sudden vision or hearing issues. This could include blurry vision, unusual colours, or decreased hearing ability. 

If you encounter these symptoms, stop the medication and immediately consult your doctor to address the situation and prevent any potential long-term effects.

Severe Allergic Reactions

Allergic reactions to Tadalafil are not common, but they can be serious. If you start getting hives, have trouble breathing, or notice swelling (like your face puffing up), you need to get medical help fast. These are signs your body is not okay with the medication.

Risks of Counterfeit Tadalafil

When it comes to Tadalafil, making sure you're getting the real deal is crucial. Here's a bit more on how to stay safe and why it matters:

Risks and Side Effects of Counterfeit Products

Fake Tadalafil poses significant dangers that cannot be emphasised enough. Counterfeit pills may lack the correct active ingredient, have incorrect dosages, or even be laced with harmful substances. 

As a result, not only may they be ineffective, but they can also lead to unexpected and serious health issues. 

To minimise these risks, it is crucial to purchase Tadalafil exclusively from reliable sources such as legitimate pharmacies and certified online retailers. This guarantees that you are obtaining a safe product that has been handled appropriately and contains precisely what it should.

Comparing with other ED meds

Tadalafil vs. Sildenafil

2 tables of Sildenafil 100mg on top of 2 teal-coloured platforms

Effect Duration: Tadalafil provides a significant benefit as it remains effective for up to 36 hours (depending on the dosage), allowing for greater flexibility and spontaneity. In contrast, Sildenafil usually lasts for approximately 4 to 5 hours.

Side Effects: Tadalafil and other medications can have similar side effects such as headaches, flushing, and indigestion. 

However, Tadalafil's longer duration means that any side effects you may have could last longer. Nevertheless, some people choose Tadalafil because its effects are spread out and can feel less intense.

Time to Effect: Sildenafil may start working quicker, usually in 30 to 60 minutes, while Tadalafil could take around 2 hours to be most effective.

Tadalafil vs. Levitra

Effect Duration: Levitra's effects typically last for 4 to 5 hours, much shorter than Tadalafil's up to 36 hours of effectiveness, making Tadalafil a popular choice for longer-lasting results.

Side Effects: Levitra and Tadalafil have similar side effects such as headaches, flushing, and nasal congestion. Some users have noted that Levitra may cause fewer visual disturbances compared to Sildenafil or Tadalafil. This could be important for those who are sensitive to changes in their vision.

Ultimately, the choice between Tadalafil, Sildenafil, and Levitra will depend on individual preferences, health considerations, and how the body reacts to each medication. 

Consulting a doctor can help determine the most suitable option based on your health history and treatment goals, ensuring that you choose the ED medication that best meets your needs while minimising side effects.

If you're dealing with erectile dysfunction, it's important to consult a doctor for guidance. At noah™, our team of experienced doctors can identify the root causes of ED and offer personalised treatment options.

Additionally, if necessary, they can prescribe the appropriate medication to assist you on your journey towards overcoming ED.

Find out what your BMI indicates

Your BMI indicates that you may be
BMI provides an estimate of weight classification. For a thorough analysis of your weight and medical options, arrange a teleconsult with a Noah doctor.

*Medical treatment may not be appropriate for you even if you have a high BMI
Your estimated weight loss in 1 year*
*In a 56-week trial with 3,731 non-diabetic overweight (BMI ≥27) or obese (BMI ≥30) participants, those who finished (1,812 patients) lost an average of 9.2% body weight with Saxenda, alongside diet and exercise.
Erectile Dysfunction
Better Sex
Erectile Dysfunction
Speak to a doctor for prescribed treatments to improve bedroom performance
Written by our Editorial Team
Last updated