Dapoxetine (Priligy) in Singapore: Dosage, Effects, Cost & How to Get It

Medically reviewed by Dr. Kevin Chua, Medical Director

Disclaimer: This article provides general medical information and is not a substitute for professional medical advice.

Introduction

Dapoxetine (brand name Priligy) is the only SSRI specifically designed and approved for on-demand treatment of premature ejaculation. Unlike traditional SSRIs used off-label for PE, dapoxetine has a rapid onset and short half-life, making it suitable for taking only when needed — 1 to 3 hours before sexual activity¹.

How Dapoxetine Works

Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI). It increases serotonin activity in the neural pathways that control ejaculation, raising the threshold for the ejaculatory reflex.

Unlike other SSRIs (paroxetine, sertraline) that take weeks to reach steady-state levels, dapoxetine reaches peak blood concentration within 1–2 hours and is rapidly eliminated. This pharmacokinetic profile enables on-demand use, which many men prefer over daily medication.

Key Pharmacological Features

• Time to peak effect: 1–2 hours
• Half-life: approximately 1.5 hours (much shorter than other SSRIs)
• Elimination: Rapid — largely cleared within 24 hours
• Mechanism: Increases serotonin in ejaculatory control centres of the brain

Dosage Guide

Dapoxetine is available in two strengths, with a clear escalation pathway based on response and tolerability.

How to Take It

• Take 1–3 hours before anticipated sexual activity
• Swallow with a full glass of water
• Can be taken with or without food
• Maximum one dose per 24 hours
• Do not take with alcohol (increased risk of fainting)

Effectiveness

Clinical trial data demonstrates meaningful improvements in ejaculatory latency and patient satisfaction with dapoxetine treatment.

Clinical Trial Results

Data from McMahon et al.¹

What This Means Practically

If your baseline ejaculatory latency is 1 minute, dapoxetine 30 mg may extend it to approximately 2.5 minutes, and 60 mg to approximately 3 minutes. While this sounds modest, the improvements in perceived control and sexual satisfaction are substantial.

Side Effects

Dapoxetine's short half-life means side effects are typically brief and mild.

Common Side Effects

• Nausea (10–20%) — the most common; usually mild
• Dizziness (5–10%)
• Headache (5–10%)
• Diarrhoea (3–5%)
• Fatigue (2–3%)

Important Safety Warning: Syncope (Fainting)

Dapoxetine can rarely cause vasovagal syncope (fainting), particularly: - In the first few hours after taking the medication - With dehydration - With alcohol consumption - When standing up quickly (orthostatic component)

Precaution: Stay well hydrated. Avoid alcohol. If you feel dizzy or lightheaded, lie down until the feeling passes. Do not drive or operate machinery if you experience dizziness.

Cost in Singapore (SGD)

Prices approximate. Updated April 2026.

Dapoxetine vs Daily SSRIs for PE

Both approaches have merit, and the choice depends on your frequency of sexual activity and preference.

FAQ

1. Can I take dapoxetine every day?

Dapoxetine is designed for on-demand use only (maximum once per 24 hours). If you want continuous coverage, your doctor may recommend a traditional daily SSRI instead.

2. Does dapoxetine work the first time?

Many men notice improvement from the first dose, but maximum benefit may take several uses as you learn the optimal timing and adjust expectations.

3. Can I combine dapoxetine with ED medication?

Yes, with caution. Combining dapoxetine with PDE5 inhibitors (sildenafil, tadalafil) can address both PE and ED. However, the combination may increase the risk of dizziness and low blood pressure. Your doctor will assess whether this combination is safe for you.

4. Does dapoxetine affect fertility?

No significant effect on fertility has been demonstrated at the recommended doses.

5. Can I drink alcohol with dapoxetine?

Alcohol is not recommended with dapoxetine. The combination increases the risk of dizziness, drowsiness, and syncope (fainting). If you do drink, limit to minimal amounts and be aware of increased side effect risk.

References

→ Return to pillar: Complete Guide to PE Treatment in Singapore

This article is for informational purposes only and does not constitute medical advice. Always consult a licensed doctor before starting any treatment.