
This article explains whether vitamin B12 deficiency leads to premature ejaculation with substantial scientific evidence. Before that, let us shed light on premature ejaculation.

This article explains whether vitamin B12 deficiency leads to premature ejaculation with substantial scientific evidence. Before that, let us shed light on premature ejaculation.
Premature ejaculation, also called PE, is the condition where the ejaculation takes place within one to three minutes of sexual arousal. Men with premature ejaculation feel depressed and embarrassed due to the inability of satisfying their partners.
There is an indirect connection between Vitamin B12 and the development of premature ejaculation.
According to the 2019 study, Vitamin B12 acts as the major component in the synthesis of serotonin which plays a vital role in ejaculation.
To make it more clear, Vitamin B12 is one of the factors involved in the formation of S‐ adenosylmethionine, a chemical essential for the synthesis of serotonin. Serotonin is a key messenger hormone that helps in stabilizing your mood, emotions, and sleep by transmitting signals between brain nerve cells.
Hence, Vitamin B12 at a normal level leads to the production of serotonin which will delay your ejaculation and stabilize your sexual behavior.
What happens if there is a deficiency in Vitamin B12? The low level of Vitamin B12 disrupts serotonin synthesis, which in turn causes premature ejaculation. Hence, you require a long-term Vitamin B12 treatment to improve ejaculation time.
Yes.
A 2019 study published in the Journal of Urological Surgery revealed a connection between premature ejaculation and Vitamin B12 deficiency.
Another 2017 study published in Andrologia journal also demonstrated that the presence of premature ejaculation was associated with a low level of Vitamin B12.
A 2018 study reported that patients with premature ejaculation had lower Vitamin B12 levels when compared with normal patients.
Vitamin B12 is naturally present in:
• Milk
• Egg
• Curd
• Chicken
• Liver
• Salmon
• Tuna
• Clams
• Oysters and mussels
• Fortified breakfast cereals
Priligy (Dapoxetine) – Priligy contains the active ingredient dapoxetine. It is a type of selective serotonin reuptake inhibitor (SSRI). It works by increasing the serotonin activity in the nervous system, thereby elevating the ejaculation time. Taking 30mg of Priligy (Dapoxetine) 30 minutes before sexual intercourse can treat premature ejaculation by absorbing quickly in one to three hours.
Lidocaine spray - The application of this topical anesthetic spray to your penis works by reducing sensitivity in the skin tissue. As your sensation remains less during foreplay, you are less likely to ejaculate earlier. Thus, lidocaine spray treats premature ejaculation by significantly improving ejaculation time and sexual satisfaction. Lidocaine spray acts quickly within five minutes.
No adverse interaction was reported between Viagra (Sildenafil) and vitamin B12. However, you should consult your doctor before taking Viagra with Vitamin B12.
Here at Noah, doctors on our platform have the right skills and experience to determine the root cause of your premature ejaculation.
Make sure to disclose your medical history accurately to the doctor. Based on your medical history, the severity of the condition, and concerns, doctors on our platform can ascertain the root cause of your PE condition and recommend the appropriate medication should you need it.
Always follow the treatment exactly as prescribed. If you experience any issues, speak to a doctor right away.


Articles featured on Noah are for informational purposes only and should not be constituted as medical advice, diagnosis or treatment. If you have any medical questions or concerns, please talk to your healthcare provider. If you're looking for a healthcare provider, click here.
Gökçen K, Gökçen P. Effects of Vitamin B12 Deficiency on Ejaculation Time in Patients with Chronic Gastritis. J Urol Surg 2019; 6:244-251 (Link)
Abd-El Raheem et al. Relation of serum vitamin B12 level to premature ejaculation Fayoum University Medical Journal 2018; 1(2): 42-46 (Link)
Kadihasanoglu M, Kilciler M, Kilciler G, et al. Relation between blood vitamin B12 levels with premature ejaculation: case-control study. Andrologia. 2017; 49(5):10.1111/and.12657. doi:10.1111/and.12657 (Link)