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Premature Ejaculation
December 9, 2023
4 Mins

Can Prozac (Fluoxetine) Help With Premature Ejaculation?

Premature ejaculation, otherwise called PE, is the most common sexual disorder affecting 30% to 50% of the male population. Fortunately, there are various ways to manage this condition. One of the medication treatments against premature ejaculation is the consumption of Prozac (fluoxetine). This article aims to discuss what Prozac (fluoxetine) is and how it helps you to get rid of premature ejaculation with substantial scientific evidence. Before that, let us throw some light on premature ejaculation.

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What Is Premature Ejaculation?

Premature ejaculation, otherwise called PE, is the condition where a man ejaculates within 1 to 3 minutes of sexual intercourse. Males with PE feel embarrassed, inferior, and dissatisfied due to the inability of satisfying their partners which leads to low quality of life for both partners.

Doctors can prescribe Prozac (fluoxetine) to manage the symptoms of premature ejaculation in men of all ages.

What Is Prozac (Fluoxetine)?

Fluoxetine, sold under the brand name Prozac, belongs to a class of long-acting drugs called SSRIs (Selective Serotonin Reuptake Inhibitors). Prozac (Fluoxetine) is usually prescribed for mood disorders that include depression, in addition to premature ejaculation. 

Prozac (Fluoxetine) is an oral tablet in 20mg concentration. For premature ejaculation, doctors can prescribe Prozac (Fluoxetine) at a low dose for daily consumption. 

Studies reported that patients found 6 to 20 times greater delay in ejaculation in one week after consuming Prozac (Fluoxetine). However, the complete effect can be observed after 2-3 weeks of medication therapy.

How Does Prozac (Fluoxetine) Work For Premature Ejaculation?

Prozac (Fluoxetine) is a type of SSRI that can increase serotonin levels in the brain. 

Serotonin is a key messenger hormone that can stabilize your emotions, mood, and sleep by carrying signals between brain nerve cells. In normal cases, serotonin after getting released by serotonin transporters gets reabsorbed back into the brain nerve cells for further use. 

The use of antidepressants like Prozac (Fluoxetine) blocks this reabsorption step. Hence, a high level of serotonin will become available to improve signal transmission between brain nerve cells. As a result, this high level of serotonin will affect your sexual behavior and cause delayed ejaculation in males.

The SSRI is called selective as they specifically affect serotonin and not any other neurotransmitter.

Is There Any Evidence To Support The Efficacy Of Prozac (Fluoxetine) Against Premature Ejaculation?


A 1996 clinical trial study showed that Prozac (Fluoxetine) could be a safe and effective alternative in treating premature ejaculation.

Even a 2020 study published in the Journal of Sexual Medicine reported that Prozac (Fluoxetine) was effective in treating premature ejaculation with a great improvement in prolonging ejaculation time, ejaculatory control, and distress levels for males.

Is It Safe To Use Prozac (Fluoxetine)?


Prozac (fluoxetine) is safe to use for premature ejaculation treatment. However, it is not recommended for men with a history of mental health issues like depression, heart problems, low blood pressure, liver, or kidney complications. Remember that Prozac (fluoxetine) should be taken together with antidepressants that help in managing your mood.

Read More: The 7 Best Vitamins and Supplements to Help with Premature Ejaculation

Is It Safe To Take Fluoxetine Along With Viagra (Sildenafil) In Patients With Premature Ejaculation?


According to the 2007 research study, fluoxetine in combination with Viagra (sildenafil) offered significantly improved prolonged ejaculation and satisfaction in sexual intercourse as compared with fluoxetine alone in patients with premature ejaculation.

Are There Any Side Effects Associated With The Use Of Prozac (Fluoxetine)?

Yes. However, the side effects associated with Prozac (fluoxetine) are usually mild which include dizziness, headache, and nausea. At times, you may experience complications such as fainting, blurred vision, and seizure.

What Are The Other Treatment Options For Premature Ejaculation?

Other treatment options include:

Priligy (Dapoxetine) - This recently developed SSRI treats premature ejaculation by absorbing rapidly in one to three hours. You can take 30mg of dapoxetine 30 minutes before sexual intercourse.

Lidocaine spray - This topical anesthetic spray can also treat premature ejaculation by improving ejaculation time and sexual satisfaction. It acts rapidly within 5 minutes. 

The Word From Noah

Make sure to check whether Prozac (fluoxetine) works for you before consuming it for treating premature ejaculation. However, keep in mind to disclose your medical history accurately to your doctor.

Here at Noah, doctors on our platform are well equipped with the knowledge to ascertain the root cause of your premature ejaculation. Based on your medical history, the severity of the condition, symptoms, and requirements, doctors on our platform will recommend the best treatment suited for you and prescribe the right medication to fix your PE problem.  

Always take your medications exactly as prescribed. In case you experience any issues, speak to a doctor right away.

Don’t let your fear and embarrassment spoil the rest of your life! Address your PE problem right away to lead a satisfactory sexual life hereafter.

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