Can Paroxetine Help Treat Premature Ejaculation?

This article aims to discuss how paroxetine can potentially treat premature ejaculation (PE) safely and effectively and other alternative treatments available for premature ejaculation.

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This article aims to discuss how paroxetine can potentially treat premature ejaculation (PE) safely and effectively and other alternative treatments available for premature ejaculation.

Before getting into this topic, let us first introduce the medical terms: premature ejaculation and paroxetine.  

What Is Premature Ejaculation?

Premature ejaculation, otherwise called PE, occurs if a man ejaculates within 1 to 3 minutes of sexual intercourse. PE can be either chronic or acquired, affecting about 20-40% of males. Both these conditions can be managed through medications, lifestyle changes, and behavioral techniques. 

Doctors prescribe paroxetine to manage the symptoms of premature ejaculation in men of all ages.

The Prolong Pill

·  Fast-acting (not fast ending!) on demand treatment
·  Increases serotonin activity, increases time to ejaculation
·  Effective, clinically proven prescription medication

What Is Paroxetine?

Paroxetine, sold under the brand name Paxil, belongs to a class of long-acting drugs called SSRIs (Selective Serotonin Reuptake Inhibitors). In addition to premature ejaculation, paroxetine is usually recommended for mood disorders that include depression. 

Paroxetine is an oral tablet in 20mg concentration. Doctors recommend taking paroxetine in dosages from 10-40mg every day to manage premature ejaculation, regardless of whether you engage in sexual intercourse.

How Does Paroxetine Work For Premature Ejaculation?

Paroxetine is a type of SSRI that has the ability to increase serotonin levels in the brain. This serotonin can impact your emotions, mood, and sleep. 

Normally, serotonin after getting released by serotonin transporters gets recycled back into the brain cell, so that it can be used again. The use of antidepressants like paroxetine block these serotonin transporters. Hence, serotonin will get accumulated between nerve cells without getting recycled. Thus, serotonin in high level will affect the sexual behavior and cause delayed ejaculation in males.

Are There Any Side Effects Associated With The Use Of Paroxetine?


The side effects are usually mild. They include:

  • Drowsiness
  • Nausea
  • Dizziness
  • Headache

Is There Any Evidence To Support The Efficacy Of Paroxetine Against Premature Ejaculation?


A 1999 clinical study published in the Journal of Urology reported that a single dose of paroxetine administered every day and as required three to four hours before planned sexual intercourse could prove to be effective in males with premature ejaculation.

A 2006 comparative clinical trial study published in the Clinical Neuropharmacology journal reported that paroxetine offered significantly better outcomes in terms of delaying ejaculation time along with satisfactory sexual intercourse when compared with dapoxetine. However, both these treatments were well tolerated.

A 2019 systematic review published in the Journal of BMC Urology reported that paroxetine offered better safety and efficacy than other drugs like placebo, escitalopram, and fluoxetine in the treatment of premature ejaculation. Additionally, paroxetine offered well-tolerated side effects.

Is It Safe To Use Paroxetine?


Paroxetine is safe to use for premature ejaculation treatment. However, it may not be recommended for males with a history of mental health issues like depression, low blood pressure, heart problems, kidney, or liver complications. Remember that paroxetine should be administered together with antidepressants. 

So, do not forget to ask your doctor whether paroxetine works for you before taking it for treating premature ejaculation.  

We could understand that it will be very difficult from your end to discuss premature ejaculation. Unless you disclose it to your doctor, they may not be able to guide you properly. 

Depending on your condition, the doctor may recommend only paroxetine or in combination with other SSRIs, or a combinational integrative approach involving medications with exercise and diet. 

Is It Safe To Take Paroxetine With Viagra?


A 2002 research study published in the Journal of Urology revealed that the combinational treatment involving both paroxetine and Viagra (sildenafil) offered significantly better results in delaying ejaculation time along with satisfactory sexual intercourse when compared to paroxetine standalone treatment. However, there was a mild increase in side effects while undergoing this combinational treatment.

Which are the other treatment options for premature ejaculation?

1. Priligy (Dapoxetine)
- It is the recently developed SSRI that can treat premature ejaculation by absorbing quickly in one to three hours. Doctor recommend to consume 30mg of dapoxetine 30 minutes before sexual intercourse.

2. Lidocaine spray - This topical anesthetic therapy can effectively improve ejaculation time and sexual satisfaction by acting quickly within 5 minutes. 

The Word from Noah

Make sure to disclose your medication details to your doctor. Only then, they can prescribe the most appropriate treatment for your condition after assessing your medications, medical history, and symptoms. Use the prescription medications as prescribed without fail. In case you experience any issues, contact the doctor right away.

Here, at Noah, our assessments are 100% confidential. So, visit our site to undergo the right treatment for premature ejaculation today!

Here at Noah, doctors on our platform are well equipped with the knowledge to ascertain the root cause of your premature ejaculation. After assessing your medical history, medications, the severity of the condition, and personal concerns, our team will recommend the best treatment suited for you and prescribe the right medication to fix your PE problem.

Don’t live the rest of your life with fears! Address this problem as soon as possible, so that you can start leading a satisfactory sexual life again.


Articles featured on Noah are for informational purposes only and should not be constituted as medical advice, diagnosis or treatment. If you have any medical questions or concerns, please talk to your healthcare provider. If you're looking for a healthcare provider, click here.


Kalejaiye O, Almekaty K, Blecher G, Minhas S. Premature ejaculation: challenging new and the old concepts. F1000Res. 2017;6:2084. Published 2017 Dec 4. doi:10.12688/f1000research.12150.1 (Link)

Zhang, D., Cheng, Y., Wu, K. et al. Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis. BMC Urol 19, 2 (2019). (Link)

McMahon CG and Touma K. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol 1999 Jun 161 18261830 (Link)

Salonia A, Maga T, Colombo R, et al. A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation. J Urol. 2002; 168(6):2486-2489. doi:10.1097/01.ju.0000038337.86140.16 (Link)

Safarinejad MR. Comparison of dapoxetine versus paroxetine in patients with premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. Clin Neuropharmacol. 2006; 29(5):243-252. doi:10.1097/01.WNF.0000228210.12194.46 (Link)

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Published On
February 3, 2022

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